The investigators concluded first-line IVIG monotherapy led to clinically relevant improvement in nearly one-half of IIM patients, the majority of whom experienced a rapid clinical response.
SCIG may be a reasonable and safe alternative for SPS patients who do not tolerate IVIG, with the caveat that allergic and injection site reactions can be a limiting factor for some patients.
The investigators concluded PUPs treated with simoctocog alfa had a lower high-titer inhibitor rate than PUPs initially treated with hamster-cell-derived recombinant FVIII products.
This trial suggests that plasma exchange with albumin replacement could slow cognitive and functional decline in Alzheimer’s disease, although further studies are warranted.
The investigators concluded lower, more frequent dosing does not further improve the efficacy of IVIG in stable IVIG-dependent CIDP patients, or result in fewer side effects.
University of Toledo investigators conducted a systematic review and meta-analysis to determine whether there may be an association between hypoalbuminemia and severe COVID-19.
Titrating the IgG trough level up to 960 mg/dL progressively reduces the infection rate in PI patients, but there is less incremental benefit above this trough level.
At the end of July, the U.S. Department of Health and Human Services extended the national public health emergency declared for the COVID-19 pandemic, which grants COVID-19 payment and regulatory flexibilities, for another 90 days.
A federal judge ruled against the American Hospital Association and other hospital groups that filed suit in December contesting afinalized rule by the U.S. Department of Health and Human Services (HHS) that requires hospitals to disclose price information, including negotiated prices with insurers.
The National Institutes of Health (NIH) has awarded a $1.95 million federal grant to researchers investigating the underlying cause (molecular mechanisms) of autoimmune diseases.
The U.S. Food and Drug Administration (FDA) issued a final rule to require new health warnings on cigarette packages and in cigarette advertisements, which feature textual statements with photo-realistic color images depicting some of the lesser-known, but serious health risks of cigarette smoking, including impact to fetal growth, cardiac disease, diabetes and more.
More than two years after receiving Spark Therapeutics’ investigational adeno-associated virus (AAV)-mediated gene therapy (SPK-8011), five adult subjects with hemophilia A exhibited stable factor VIII (FVIII) expression, with no evidence of FVIII inhibitors or a cellular immune response.
