Monday, Feb 18, 2019

Banner Image - Patient Safety, Product Integrity, Fair Pricing

Severe Flu Increases Risks for Pregnant Women and Their Babies

doctor about to administer vaccination to a pregnant woman

In this Issue


•	IVIG/Albumin Supply Index
•	Open Market Pricing
•	New Products from FFF
•	Current Medicare IVIG / SCIG Rates
•	Resources
•	Subscribe to IG Living and BioSupply Trends Quarterly

A new study shows pregnant women who are hospitalized in the intensive care unit with influenza (flu) are four times more likely to deliver babies prematurely and four and a half times more likely to have a baby of low birth weight — underscoring the need for them to receive the influenza vaccine and get prompt treatment with antiviral medications. [ read more ]

Studies Show Privigen Is Safe and Effective in Treating CIDP

Results from the PRIMA and PATH studies show Privigen (intravenous immune globulin) is a safe and effective therapy for pretreated chronic inflammatory demyelinating polyneuropathy (CIDP) patients. [ read more ]

Study Shows SCIG 20% Well-Tolerated in Pediatric PI Patients

In a study to assess the safety and tolerability of relatively high infusion rates and volumes per site in a broad pediatric primary immunodeficiency disease (PI) patient population treated with subcutaneous immune globulin (SCIG) 20% (Cuvitru), researchers found it was well-tolerated. [ read more ]

Industry News

From Takeda Pharmaceuticals

On Jan. 8, Takeda Pharmaceutical Company Limited completed its acquisition of Shire, making the company, which is headquartered in Japan, a leader in providing targeted treatments in gastroenterology, neuroscience, oncology, rare diseases and plasma-derived therapies.
[ read more ]

From Sanofi Pasteur

Sanofi Pasteur's Adacel Tdap (tetanus toxoid, reduced diphtheria toxoid and acellular pertussis) absorbed vaccine has been granted expanded indication by the U.S. Food and Drug Administration to include repeat vaccinations for tetanus, diphtheria and pertussis. With this expanded indication, Adacel is the first and only Tdap vaccine approved for repeated dose in people aged 10 years to 64 years, eight years or more after their first vaccination, in the U.S. [ read more ]

From Ablynx

The U.S. Food and Drug Administration has approved Cablivi (caplacizumab-yhdp) injection, the first therapy specifically indicated, in combination with plasma exchange and immunosuppressive therapy, for the treatment of adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), a rare and life-threatening disorder that causes blood clotting. [ read more ]

IVIG & Albumin Supply Index

Log in to BioSupply for IVIG and Albumin Product Pricing

What's New at FFF

• ANDEXXA (PORTOLA)

ANDEXXA [coagulation factor Xa (recombinant), inactivated-zhzo] is the first and only antidote indicated for patients treated with rivaroxaban and apixaban, when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding. It is supplied in cartons of four single-use vials containing 100 mg of ANDEXXA as a white to off-white lyophilized cake or powder.

For more information about ANDEXXA, login to biosupply.fffenterprises.com

• OMIDRIA (OMEROS)

Omidria is an alpha 1-adrenergic receptor agonist and nonselective cyclooxygenase inhibitor that is added to ophthalmic irrigation solution used during cataract surgery or intraocular lens replacement. It is indicated for maintaining pupil size by preventing intraoperative miosis and reducing postoperative ocular pain.

For more information about OMIDRIA, login to biosupply.fffenterprises.com

• ZEMDRI (ACHAOGEN)

ZEMDRI (plazomicin) is indicated in patients 18 years of age or older for the treatment of complicated urinary tract infections, including pyelonephritis caused by the following susceptible microorganism(s): Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Enterobacter cloacae. It is supplied in single-dose (50 mg) 10-mL vials fitted with flip-off seals with royal blue polypropylene buttons as a clear, colorless to yellow, sterile solution.

For more information about ZEMDRI, login to biosupply.fffenterprises.com

• NAROPIN (FRESENIUS KABI)

Naropin (Ropivacaine) hydrochloride injection is indicated for the production of local or regional anesthesia for surgery and for acute pain management. Naropin is preservative-free and is available through FFF in single dose containers in 2 (0.2%) and 5 (0.5%) concentrations.

For more information about NAROPIN, login to biosupply.fffenterprises.com
*Call for eligibility through your GPO affiliation.

• XYLOCAINE (FRESENIUS KABI)

Xylocaine (lidocaine HCI) injections are indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks. Xylocaine is available in the following dosage forms: Xylocaine-MPF, Xylocaine MPF with Epinephrine and Xylocaine with Epinephrine.

For more information about XYLOCAINE, login to biosupply.fffenterprises.com
*Call for eligibility through your GPO affiliation.

• DIPHENHYDRAMINE (FRESENIUS KABI)

Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when Diphenhydramine hydrochloride in the oral form is impractical: antihistaminic, motion sickness and antiparkinsonism. Diphenhydramine is available in 50 mg/mL SDV packs of 25.

For more information about DIPHENHYDRAMINE, login to biosupply.fffenterprises.com
*Call for eligibility through your GPO affiliation.

• DILTIAZEM (AKORN)

Diltiazem hydrochloride injection is a calcium ion influx inhibitor (slow channel blocker or calcium channel antgonist) indicated for the treatment of atrial fibrillation or atrial flutter and paroxysmal supraventricular tachycardia. Diltiazem is available through FFF in the following strengths and sizes: 25 mg/5 mL, 50 mg/10 mL and 125 mg/25 mL.

For more information about DILTIAZEM, login to biosupply.fffenterprises.com
*Call for eligibility through your GPO affiliation.

• ONDANSETRON (HERITAGE PHARMACEUTICALS INC)

ONDANSETRON injection, USP is a 5-HT3 receptor antagonist indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy and the prevention of postoperative nausea and/or vomiting. Ondansetron is available through FFF in 4 mg/2 mL vials packs of 25.

For more information about ONDANSETRON, login to biosupply.fffenterprises.com

• POTASSIUM CHLORIDE (HOSPIRA)

Potassium Chloride for Injection Concentrate, USP is indicated in the treatment of potassium deficiency states when oral replacement is not feasible. Potassium Chloride is available through FFF in the following concentrations and sizes: 10 mEq/5 mL, 20 mEq/10 mL and 40 mEq/20 mL.

For more information about POTASSIUM CHLORIDE,
login to biosupply.fffenterprises.com

These products can be ordered from FFF Enterprise's BioSupply Online Ordering System or by calling
Wow! Customer Care at (800) 843-7477.

Current Medicare IVIG / SCIG Rates

Rates per gram are effective January 1, 2019, through March 31, 2019.

Product	J Codes	ASP + 6% (before sequester)	ASP + 4.3%* (after sequester)
IVIG
Flebogamma	J1572	$68.79	$67.69
Gammagard S/D	J1566	$86.22	$84.84
Gammaplex	J1557	$91.78	$90.31
Octagam	J1568	$70.94	$69.80
Privigen	J1459	$80.64	$79.34
SCIG
CUVITRU	J1555	$136.05	$133.87
Hizentra	J1559	$101.12	$99.50
HyQvia	J1575	$141.78	$139.51
IVIG / SCIG
Gammagard Liquid	J1569	$84.45	$83.10
Gammaked	J1561	$80.23	$78.94
Gamunex-C	J1561	$80.23	$78.94

*Reflects 2% sequestration reduction applied to 80% Medicare payment portion as required under Budget Control Act of 2011.

Log in to BioSupply for Immune Globulin Products

Resources

FFF customers may order the following complementary resources to help you with your practice:


•	IG Immune Globulin (Human)
•	Hyperimmune Globulins
•	Anti-Inhibitor, Factor VIIa & IX
•	Factor VIII & von Willebrand Factor
•	Seasonal Influenza Vaccine

Subscribe to IG Living

IG Living is the only magazine for the immune globulin (IG) community for patients who suffer from chronic illness and their caregivers.

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Trends Quarterly

BioSupply Trends Quarterly magazine is the definitive source for industry trends, news and information for the biopharmaceuticals marketplace.